Saxagliptin Functional Indications

Saxagliptin Functional Indications

For type 2 diabetes

Single drug therapy: can be used as a single drug treatment, on the basis of diet and exercise to improve blood sugar control.

Combined therapy: When the blood glucose control of metformin hydrochloride is not good, it can be combined with metformin hydrochloride to improve blood glucose control on the basis of diet and exercise.

Important Use restrictions: because the effectiveness of type 1 diabetes mellitus and diabetic ketoacidosis is not yet determined, Saxagliptin is not used in patients with type 1 diabetes or diabetic ketoacidosis.

Usage dosage of Saxagliptin

Oral, recommended dose 5mg daily 1 times, the time of taking medicine is not affected by eating.

Patients with renal insufficiency

Patients with renal insufficiency do not need to adjust dosage. Patients with moderate to severe renal insufficiency have limited experience in clinical research and therefore do not recommend Saxagliptin for this type of patient (see note box pharmacokinetics).

Patients with impaired liver function

Patients with mild to moderate liver dysfunction do not need to be adjusted for dose (pharmacokinetics). Saxagliptin used in patients with moderate liver damage should be cautious and not recommended for patients with severe liver damage. (See Considerations)

Strong-effect cytochrome P4503A4/5 (CYP3A4/5) inhibitor

When combined with potent CYP3A4/5 inhibitors (such as ketoconazole, Atazanavir, clarithromycin, Indanone, Itraconazole, naproxen, naphthalene, Ritonavir, Saquinavir, and doxycycline), the dosage of Saxagliptin should be limited to 2. The $number day. "